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Enhanced sampling methods can predict free energy landscapes associated with protein ligand binding characterizing the involved intermolecular interactions in a precise way However these in silico approaches can be challenged by induced fit effects Here we present a variant of volume based metadynamics tailored to tackle this problem in a general and efficient way The

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Human nutrition deals with the provision of essential nutrients in food that are necessary to support human life and good health Poor nutrition is a chronic problem often linked to poverty food security or a poor understanding of nutritional requirements Malnutrition and its consequences are large contributors to deaths physical deformities and disabilities worldwide

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